Expression of targeting protein for TPX2 in bladder cancer and its clinical significance

Abstract
Objective: To clarify the connection between TPX2 expression and clinicopathological characteristics of bladder cancer, so as to evaluate the function of TPX2 as a prognosis marker in bladder cancer.
Methods: GEO datasets were collected and expression profile and clinical information were analyzed. GSEA was conducted to explore the gene sets enriched in TPX2 high-expression samples.
Results: The expression of TPX2 was up-regulated in bladder cancer (P<0.0001); TPX2 expression was significantly associated with age, sex, T stage, N stage, progression, grade. Higher expression of TPX2 indicated poor prognosis in bladder cancer. GSEA indicated that TPX2 regulates gene sets associated with spermatogenesis,unfolded protein response, PI3K/ AKT/mTOR signaling, mTORC1 signaling, cholesterol homeostasis, mitotic spindle, glycolysis, G2M checkpoint, E2Ftargets, myctargets.
Conclusion: TPX2 is highly expressed in multiple tumors and functions as potential marker and target in diagnosis and treatment in bladder cancer.